Background: The reported rise in drug-resistant bacteria, as well as the prevalence of oxidative stress-related disorders, motivated the need for novel antimicrobial and antioxidants activity. The synthesis of gly-gly based dipeptides bearing sulphonamide functionalities is reported. Methodology: The base promoted reaction of appropriate substituted benzenesulphonyl chloride with L-glycine afforded compounds (3a-3b) and the condensation reaction of (3a-3b) with carboxamide derivatives gave the targeted products (7a-7b) using peptide coupling reagent. The characterization of compounds was done using 1HNMR, 13CNMR, FTIR and HRMS. Results: In the in vitro antimicrobial activity, compounds 7a (MIC 6.10 mg/mL), 7ai (MIC 7.01 mg/mL), 7b (MIC 7.42 mg/mL), 7bi (MIC 6.32 mg/mL) was most potent against S. aureus, B. subtilis, P. aeruginosa and E. coli respectively. Compounds 7a (MIC 6.90 mg/mL) and 7b (MIC 6.48 mg/mL) were most active against C. Albicans and A. Niger respectively. Compound 7a and 7bi (85.00% and 88.78% at 25mg/mL) exhibits excellent percentage inhibition antioxidant activities comparable with vitamin C (90.78% at 25mg/mL) and alsocompound 7bi had the best IC50 values of 0.7674 mg/mL. Conclusion: The synthesized compounds were found to be potent antibacterial, antifungal and antioxidant agents.
| Published in | American Journal of Applied Scientific Research (Volume 9, Issue 3) |
| DOI | 10.11648/j.ajasr.20230903.14 |
| Page(s) | 109-114 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2023. Published by Science Publishing Group |
Synthesis, Benzenesulphonamide, Dipeptide, Antimicrobial Activity, Antifungal Activity, Antioxidant Activity
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APA Style
Ike Ozoemena Christian, Okoro Uchechukwu Christopher, Aguoma Chinedu Chris, Orjioke Nwakaego Marytheresa, Ugwu David Izuchukwu, et al. (2023). Synthesis, Antimicrobial and Antioxidant Properties of Gly-Gly Based Dipeptide. American Journal of Applied Scientific Research, 9(3), 109-114. https://doi.org/10.11648/j.ajasr.20230903.14
ACS Style
Ike Ozoemena Christian; Okoro Uchechukwu Christopher; Aguoma Chinedu Chris; Orjioke Nwakaego Marytheresa; Ugwu David Izuchukwu, et al. Synthesis, Antimicrobial and Antioxidant Properties of Gly-Gly Based Dipeptide. Am. J. Appl. Sci. Res. 2023, 9(3), 109-114. doi: 10.11648/j.ajasr.20230903.14
AMA Style
Ike Ozoemena Christian, Okoro Uchechukwu Christopher, Aguoma Chinedu Chris, Orjioke Nwakaego Marytheresa, Ugwu David Izuchukwu, et al. Synthesis, Antimicrobial and Antioxidant Properties of Gly-Gly Based Dipeptide. Am J Appl Sci Res. 2023;9(3):109-114. doi: 10.11648/j.ajasr.20230903.14
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Download@article{10.11648/j.ajasr.20230903.14,
author = {Ike Ozoemena Christian and Okoro Uchechukwu Christopher and Aguoma Chinedu Chris and Orjioke Nwakaego Marytheresa and Ugwu David Izuchukwu and Nweloke Regina Chinyere and Orie Kingsley John and Nsude Okechukwu Paul and Okoye Nebeolisa Johnson and Eze Cosmos Chibuike and Attah Solomon Izuchukwu and Ugwu Michael Chukwuemeka},
title = {Synthesis, Antimicrobial and Antioxidant Properties of Gly-Gly Based Dipeptide},
journal = {American Journal of Applied Scientific Research},
volume = {9},
number = {3},
pages = {109-114},
doi = {10.11648/j.ajasr.20230903.14},
url = {https://doi.org/10.11648/j.ajasr.20230903.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajasr.20230903.14},
abstract = {Background: The reported rise in drug-resistant bacteria, as well as the prevalence of oxidative stress-related disorders, motivated the need for novel antimicrobial and antioxidants activity. The synthesis of gly-gly based dipeptides bearing sulphonamide functionalities is reported. Methodology: The base promoted reaction of appropriate substituted benzenesulphonyl chloride with L-glycine afforded compounds (3a-3b) and the condensation reaction of (3a-3b) with carboxamide derivatives gave the targeted products (7a-7b) using peptide coupling reagent. The characterization of compounds was done using 1HNMR, 13CNMR, FTIR and HRMS. Results: In the in vitro antimicrobial activity, compounds 7a (MIC 6.10 mg/mL), 7ai (MIC 7.01 mg/mL), 7b (MIC 7.42 mg/mL), 7bi (MIC 6.32 mg/mL) was most potent against S. aureus, B. subtilis, P. aeruginosa and E. coli respectively. Compounds 7a (MIC 6.90 mg/mL) and 7b (MIC 6.48 mg/mL) were most active against C. Albicans and A. Niger respectively. Compound 7a and 7bi (85.00% and 88.78% at 25mg/mL) exhibits excellent percentage inhibition antioxidant activities comparable with vitamin C (90.78% at 25mg/mL) and alsocompound 7bi had the best IC50 values of 0.7674 mg/mL. Conclusion: The synthesized compounds were found to be potent antibacterial, antifungal and antioxidant agents.},
year = {2023}
}
TY - JOUR T1 - Synthesis, Antimicrobial and Antioxidant Properties of Gly-Gly Based Dipeptide AU - Ike Ozoemena Christian AU - Okoro Uchechukwu Christopher AU - Aguoma Chinedu Chris AU - Orjioke Nwakaego Marytheresa AU - Ugwu David Izuchukwu AU - Nweloke Regina Chinyere AU - Orie Kingsley John AU - Nsude Okechukwu Paul AU - Okoye Nebeolisa Johnson AU - Eze Cosmos Chibuike AU - Attah Solomon Izuchukwu AU - Ugwu Michael Chukwuemeka Y1 - 2023/07/24 PY - 2023 N1 - https://doi.org/10.11648/j.ajasr.20230903.14 DO - 10.11648/j.ajasr.20230903.14 T2 - American Journal of Applied Scientific Research JF - American Journal of Applied Scientific Research JO - American Journal of Applied Scientific Research SP - 109 EP - 114 PB - Science Publishing Group SN - 2471-9730 UR - https://doi.org/10.11648/j.ajasr.20230903.14 AB - Background: The reported rise in drug-resistant bacteria, as well as the prevalence of oxidative stress-related disorders, motivated the need for novel antimicrobial and antioxidants activity. The synthesis of gly-gly based dipeptides bearing sulphonamide functionalities is reported. Methodology: The base promoted reaction of appropriate substituted benzenesulphonyl chloride with L-glycine afforded compounds (3a-3b) and the condensation reaction of (3a-3b) with carboxamide derivatives gave the targeted products (7a-7b) using peptide coupling reagent. The characterization of compounds was done using 1HNMR, 13CNMR, FTIR and HRMS. Results: In the in vitro antimicrobial activity, compounds 7a (MIC 6.10 mg/mL), 7ai (MIC 7.01 mg/mL), 7b (MIC 7.42 mg/mL), 7bi (MIC 6.32 mg/mL) was most potent against S. aureus, B. subtilis, P. aeruginosa and E. coli respectively. Compounds 7a (MIC 6.90 mg/mL) and 7b (MIC 6.48 mg/mL) were most active against C. Albicans and A. Niger respectively. Compound 7a and 7bi (85.00% and 88.78% at 25mg/mL) exhibits excellent percentage inhibition antioxidant activities comparable with vitamin C (90.78% at 25mg/mL) and alsocompound 7bi had the best IC50 values of 0.7674 mg/mL. Conclusion: The synthesized compounds were found to be potent antibacterial, antifungal and antioxidant agents. VL - 9 IS - 3 ER -
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