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Antidiarrheal Potential of Adenanthera pavonina Linn Seed Aqueous Extract in Experimental Animals

Received: 4 April 2017     Accepted: 6 May 2017     Published: 11 August 2017
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Abstract

The objective of present investigation is to investigate antidiarrheal potential of Adenanthera pavonina seed aqueous extract (APSAE) in experimental animals. The APSAE was administered orally to three groups of animals (six per group) in order to investigate activity against castor oil and magnesium sulphate-induced diarrhoea in rats. The effect of extract on gastrointestinal transit using charcoal and castor oil induced enteropooling was assessed using Loperamide 3mg/kg was used as reference standard. Oral administration of APSAE at doses 50,100 and 200 mg/kg exhibited dose-dependent significant (P<0.05) antidiarrheal potential against castor oil and magnesium sulphate-induced diarrhoea in rats. APSAE also produced significant (P<0.05) reduction in propulsive movement in castor oil-induced gastrointestinal transit using charcoal meal in rats when compared with reference standard Loperamide. These findings demonstrate that Adenanthera pavonina seed aqueous extract shows significant antidiarrhoeal potential, thus justifying its traditional use in diarrhoea.

Published in International Journal of Chinese Medicine (Volume 1, Issue 4)
DOI 10.11648/j.ijcm.20170104.12
Page(s) 116-120
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Adenanthera pavonina, Diarrhoea, Castor Oil, MgSO4, Loperamide

References
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Cite This Article
  • APA Style

    Ramdas Pandhare, Sangameswaran Balakrishnan, Gaurav Bangar, Pramod Dighe, Vinayak Deshmukh. (2017). Antidiarrheal Potential of Adenanthera pavonina Linn Seed Aqueous Extract in Experimental Animals. International Journal of Chinese Medicine, 1(4), 116-120. https://doi.org/10.11648/j.ijcm.20170104.12

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    ACS Style

    Ramdas Pandhare; Sangameswaran Balakrishnan; Gaurav Bangar; Pramod Dighe; Vinayak Deshmukh. Antidiarrheal Potential of Adenanthera pavonina Linn Seed Aqueous Extract in Experimental Animals. Int. J. Chin. Med. 2017, 1(4), 116-120. doi: 10.11648/j.ijcm.20170104.12

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    AMA Style

    Ramdas Pandhare, Sangameswaran Balakrishnan, Gaurav Bangar, Pramod Dighe, Vinayak Deshmukh. Antidiarrheal Potential of Adenanthera pavonina Linn Seed Aqueous Extract in Experimental Animals. Int J Chin Med. 2017;1(4):116-120. doi: 10.11648/j.ijcm.20170104.12

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  • @article{10.11648/j.ijcm.20170104.12,
      author = {Ramdas Pandhare and Sangameswaran Balakrishnan and Gaurav Bangar and Pramod Dighe and Vinayak Deshmukh},
      title = {Antidiarrheal Potential of Adenanthera pavonina Linn Seed Aqueous Extract in Experimental Animals},
      journal = {International Journal of Chinese Medicine},
      volume = {1},
      number = {4},
      pages = {116-120},
      doi = {10.11648/j.ijcm.20170104.12},
      url = {https://doi.org/10.11648/j.ijcm.20170104.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcm.20170104.12},
      abstract = {The objective of present investigation is to investigate antidiarrheal potential of Adenanthera pavonina seed aqueous extract (APSAE) in experimental animals. The APSAE was administered orally to three groups of animals (six per group) in order to investigate activity against castor oil and magnesium sulphate-induced diarrhoea in rats. The effect of extract on gastrointestinal transit using charcoal and castor oil induced enteropooling was assessed using Loperamide 3mg/kg was used as reference standard. Oral administration of APSAE at doses 50,100 and 200 mg/kg exhibited dose-dependent significant (PAdenanthera pavonina seed aqueous extract shows significant antidiarrhoeal potential, thus justifying its traditional use in diarrhoea.},
     year = {2017}
    }
    

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    T1  - Antidiarrheal Potential of Adenanthera pavonina Linn Seed Aqueous Extract in Experimental Animals
    AU  - Ramdas Pandhare
    AU  - Sangameswaran Balakrishnan
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    AU  - Pramod Dighe
    AU  - Vinayak Deshmukh
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    N1  - https://doi.org/10.11648/j.ijcm.20170104.12
    DO  - 10.11648/j.ijcm.20170104.12
    T2  - International Journal of Chinese Medicine
    JF  - International Journal of Chinese Medicine
    JO  - International Journal of Chinese Medicine
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    PB  - Science Publishing Group
    SN  - 2578-9473
    UR  - https://doi.org/10.11648/j.ijcm.20170104.12
    AB  - The objective of present investigation is to investigate antidiarrheal potential of Adenanthera pavonina seed aqueous extract (APSAE) in experimental animals. The APSAE was administered orally to three groups of animals (six per group) in order to investigate activity against castor oil and magnesium sulphate-induced diarrhoea in rats. The effect of extract on gastrointestinal transit using charcoal and castor oil induced enteropooling was assessed using Loperamide 3mg/kg was used as reference standard. Oral administration of APSAE at doses 50,100 and 200 mg/kg exhibited dose-dependent significant (PAdenanthera pavonina seed aqueous extract shows significant antidiarrhoeal potential, thus justifying its traditional use in diarrhoea.
    VL  - 1
    IS  - 4
    ER  - 

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Author Information
  • Department of Pharmacology, M. E. S’s College of Pharmacy, Savitribai Phule Pune University, Newasa, India

  • S. S. M. College of Pharmacy, Erode, India

  • M. E. S’s College of Pharmacy, Savitribai Phule Pune University, Newasa, India

  • M. E. S’s College of Pharmacy, Savitribai Phule Pune University, Newasa, India

  • M. E. S’s College of Pharmacy, Savitribai Phule Pune University, Newasa, India

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