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Study on the Pharmacological Mechanism of Yinqiao Antipyreti Granules Against Influenza Based on Network Pharmacology

Received: 16 October 2020     Accepted: 2 November 2020     Published: 16 December 2020
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Abstract

Objective: To explore the anti-influenza pharmacological mechanism of Yinqiao Antipyreti Granules by using network pharmacology. Method: Retrieve the main active ingredients, corresponding targets and target genes of Yinqiao Antipyreti Granules on the website of Chinese Medicine System Pharmacology Technology Platform (TCMSP), obtain the relevant target genes of influenza through the Human Gene Database (Gene Cards), and transfer the drugs The target of the active ingredient is mapped to the influenza target, and the intersection target obtained is the predicted target of Yinqiao Ture granules against influenza. Cytoscape 3.8.0 software was used to construct a drug active ingredient-intersection target network model, and key active ingredients were selected. Use the STRING website to construct an intersection target protein interaction network (PPI) and select key target genes. Enriched analysis of GO and KEGG pathways using Metascape on intersection targets. Results: There are 136 active ingredients in Yinqiao Antipyretic Granules and 131 anti-influenza-related targets. Conclusion: The main components of Yinqiao Antipyretic Granules are quercetin, luteolin, naringenin, formononetin, IL-6, STAT3, MAPK14, CASP3 and other gene targets, to suppress inflammatory response, regulate immunity, reduce the symptoms of influenza, and thus play an anti-influenza therapeutic role.

Published in International Journal of Chinese Medicine (Volume 4, Issue 4)
DOI 10.11648/j.ijcm.20200404.12
Page(s) 82-89
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Yinqiao Antipyreti Granules, Influenza, Network Pharmacology

References
[1] Zhang Y, Lyu C, Fong SYK, Wang Q, Li C, Ho NJ, Chan KS, Yan X and Zuo Z. (2019). Evaluation of potential herb-drug interactions between oseltamivir and commonly used anti-influenza Chinese medicinal herbs. Journal of Ethnopharmacology 243: 112097.
[2] Qiaomu C, Lijie H and Wei W. (2003). Clinical Application and Pharmacological Experimental Study of Yinqiao Powder. 09: 37-39.
[3] Baoguo Z, Yue C and Qingfang L. (2010). Modern Clinical Application of Liuyi Powder. 32: 467-470.
[4] Ehrhardt C, Seyer R, Hrincius ER, Eierhoff T, Wolff T and Ludwig S. (2010). Interplay between influenza A virus and the innate immune signaling. Microbes Infect 12: 81-87.
[5] Hale BG, Albrecht RA and García-Sastre A. (2010). Innate immune evasion strategies of influenza viruses. Future microbiology 5: 23-41.
[6] Ludwig S. (2009). Targeting cell signalling pathways to fight the flu: towards a paradigm change in anti-influenza therapy. Journal of Antimicrobial Chemotherapy 64: 1-4.
[7] Jianguo Z, Jining Z and Xunjuan H. (2014). Advances in neuraminidase inhibitors [J]. Chemical and Biological Engineering. Chemical and Biological Engineering 31: 1-5.
[8] Takashima K, Matsushima M, Hashimoto K, Nose H, Sato M, Hashimoto N, Hasegawa Y and Kawabe T. (2014). Protective effects of intratracheally administered quercetin on lipopolysaccharide-induced acute lung injury. Respir Res 15: 150.
[9] Birt DF, Hendrich S and Wang W. (2001). Dietary agents in cancer prevention: flavonoids and isoflavonoids. Pharmacol Ther 90: 157-177.
[10] Xu L, Su W, Jin J, Chen J, Li X, Zhang X, Sun M, Sun S, Fan P, An D, Zhang H, Zhang X, Kong W, Ma T and Jiang C. (2014). Identification of luteolin as enterovirus 71 and coxsackievirus A16 inhibitors through reporter viruses and cell viability-based screening. Viruses 6: 2778-2795.
[11] Xagorari A, Papapetropoulos A, Mauromatis A, Economou M, Fotsis T and Roussos C. (2001). Luteolin inhibits an endotoxin-stimulated phosphorylation cascade and proinflammatory cytokine production in macrophages. J Pharmacol Exp Ther 296: 181-187.
[12] Kotanidou a, Xagorari a, Bagli e, Kitsanta p, Fotsis t, Papapetropoulos a and Roussos c. (2002). Luteolin Reduces Lipopolysaccharide-induced Lethal Toxicity and Expression of Proinflammatory Molecules in Mice. American journal of respiratory and critical care medicine 165: 818-823.
[13] Zhou Y, Du B, Tan Y, Wu Y, Liu X, Liu J, Yi H and Li Y. (2010). Inhibition and induction of apoptosis of rat hepatocellular carcinoma cell line CBRH7919 by kaolin. Journal of Guangzhou University of Traditional Chinese Medicine 27.
[14] Dong X, Fu J, Yin X, Cao S, Li X, Lin L and Ni J. (2016). Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics. Phytother Res 30: 1207-1218.
[15] Mir IA and Tiku AB. (2015). Chemopreventive and Therapeutic Potential of "Naringenin," a Flavanone Present in Citrus Fruits. Nutrition and Cancer 67: 27-42.
[16] Tianzhu Z, Chunhua M and Xiangze F. (2016). The protective effect of naringin on acute lung injury induced by lipopolysaccharide in mice. Phytother Res 30: 1207-1218.
[17] Park S, Bazer FW, Lim W and Song G. (2018). The O-methylated isoflavone, formononetin, inhibits human ovarian cancer cell proliferation by sub G0/G1 cell phase arrest through PI3K/AKT and ERK1/2 inactivation. J Cell Biochem 119: 7377-7387.
[18] Zhang X, Liang M, Huang W, Guo Y, Lu H and Xin M. (2015). Formononetin induces apoptosis in bladder cancer cells. Chinese Journal of Public Health 31: 314-317.
[19] Dong CC, Zhong L, Zhang GY, Wang ZR, Ran F and Chen X. (2016). Inhibitory effect and mechanism of formononetin on nude mouse model bearing human gastric cancer cells MKN-45. Chongqing Medical Journal: 4482-4483.
[20] Liang X, Wei S, Li L, Xie W, Huang Y and Chen J. (2017). Formononetin was used to treat SOD, MDA and GSHPx in mice and the effect of Bun. Journal of Hubei University of Science and Technology (Medical Sciences) 31.
[21] Liu JZ, van Sommeren S, Huang H, Ng SC, Alberts R, Takahashi A, Ripke S, Lee JC, Jostins L, Shah T, Abedian S, Cheon JH, Cho J, Dayani NE, Franke L, Fuyuno Y, Hart A, Juyal RC, Juyal G, Kim WH, Morris AP, Poustchi H, Newman WG, Midha V, Orchard TR, Vahedi H, Sood A, Sung JY, Malekzadeh R, Westra HJ, Yamazaki K, Yang SK, Barrett JC, Alizadeh BZ, Parkes M, Bk T, Daly MJ, Kubo M, Anderson CA and Weersma RK. (2015). Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. Nat Genet 47: 979-986.
[22] Neufert C, Pickert G, Zheng Y, Wittkopf N, Warntjen M, Nikolae A, Ouyang W, Neurath MF and Becker C. (2014). Activation of epithelial STAT3 regulates intestinal homeostasis. Cell Cycle 9: 652-655.
[23] Yang Z, Yuan L, Wei H, Jing-rong C, Hong-wei J, Liang-ren Z and Zhen-ming L. (2018). Advances on anti-neoplastic STAT3 inhibitors. Acta Pharmaceutica Sinica 53: 1598-1608.
[24] Kosai K, Seki M, Tanaka A, Morinaga Y, Imamura Y, Izumikawa K, Kakeya H, Yamamoto Y, Yanagihara K, Tomono K and Kohno S. (2011). Increase of apoptosis in a murine model for severe pneumococcal pneumonia during influenza A virus infection. Jpn J Infect Dis 64: 451-457.
[25] Li Z, Li L, Zhao S, Li J, Zhou H, Zhang Y, Yang Z and Yuan B. (2018). Re-understanding anti-influenza strategy: attach equal importance to antiviral and anti-inflammatory therapies. J Thorac Dis 10: S2248-S2259.
Cite This Article
  • APA Style

    Suishan Qiu, Lianfang Xue, Huiting Zhong, Leping Li, Hui Liu. (2020). Study on the Pharmacological Mechanism of Yinqiao Antipyreti Granules Against Influenza Based on Network Pharmacology. International Journal of Chinese Medicine, 4(4), 82-89. https://doi.org/10.11648/j.ijcm.20200404.12

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    ACS Style

    Suishan Qiu; Lianfang Xue; Huiting Zhong; Leping Li; Hui Liu. Study on the Pharmacological Mechanism of Yinqiao Antipyreti Granules Against Influenza Based on Network Pharmacology. Int. J. Chin. Med. 2020, 4(4), 82-89. doi: 10.11648/j.ijcm.20200404.12

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    AMA Style

    Suishan Qiu, Lianfang Xue, Huiting Zhong, Leping Li, Hui Liu. Study on the Pharmacological Mechanism of Yinqiao Antipyreti Granules Against Influenza Based on Network Pharmacology. Int J Chin Med. 2020;4(4):82-89. doi: 10.11648/j.ijcm.20200404.12

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  • @article{10.11648/j.ijcm.20200404.12,
      author = {Suishan Qiu and Lianfang Xue and Huiting Zhong and Leping Li and Hui Liu},
      title = {Study on the Pharmacological Mechanism of Yinqiao Antipyreti Granules Against Influenza Based on Network Pharmacology},
      journal = {International Journal of Chinese Medicine},
      volume = {4},
      number = {4},
      pages = {82-89},
      doi = {10.11648/j.ijcm.20200404.12},
      url = {https://doi.org/10.11648/j.ijcm.20200404.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcm.20200404.12},
      abstract = {Objective: To explore the anti-influenza pharmacological mechanism of Yinqiao Antipyreti Granules by using network pharmacology. Method: Retrieve the main active ingredients, corresponding targets and target genes of Yinqiao Antipyreti Granules on the website of Chinese Medicine System Pharmacology Technology Platform (TCMSP), obtain the relevant target genes of influenza through the Human Gene Database (Gene Cards), and transfer the drugs The target of the active ingredient is mapped to the influenza target, and the intersection target obtained is the predicted target of Yinqiao Ture granules against influenza. Cytoscape 3.8.0 software was used to construct a drug active ingredient-intersection target network model, and key active ingredients were selected. Use the STRING website to construct an intersection target protein interaction network (PPI) and select key target genes. Enriched analysis of GO and KEGG pathways using Metascape on intersection targets. Results: There are 136 active ingredients in Yinqiao Antipyretic Granules and 131 anti-influenza-related targets. Conclusion: The main components of Yinqiao Antipyretic Granules are quercetin, luteolin, naringenin, formononetin, IL-6, STAT3, MAPK14, CASP3 and other gene targets, to suppress inflammatory response, regulate immunity, reduce the symptoms of influenza, and thus play an anti-influenza therapeutic role.},
     year = {2020}
    }
    

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  • TY  - JOUR
    T1  - Study on the Pharmacological Mechanism of Yinqiao Antipyreti Granules Against Influenza Based on Network Pharmacology
    AU  - Suishan Qiu
    AU  - Lianfang Xue
    AU  - Huiting Zhong
    AU  - Leping Li
    AU  - Hui Liu
    Y1  - 2020/12/16
    PY  - 2020
    N1  - https://doi.org/10.11648/j.ijcm.20200404.12
    DO  - 10.11648/j.ijcm.20200404.12
    T2  - International Journal of Chinese Medicine
    JF  - International Journal of Chinese Medicine
    JO  - International Journal of Chinese Medicine
    SP  - 82
    EP  - 89
    PB  - Science Publishing Group
    SN  - 2578-9473
    UR  - https://doi.org/10.11648/j.ijcm.20200404.12
    AB  - Objective: To explore the anti-influenza pharmacological mechanism of Yinqiao Antipyreti Granules by using network pharmacology. Method: Retrieve the main active ingredients, corresponding targets and target genes of Yinqiao Antipyreti Granules on the website of Chinese Medicine System Pharmacology Technology Platform (TCMSP), obtain the relevant target genes of influenza through the Human Gene Database (Gene Cards), and transfer the drugs The target of the active ingredient is mapped to the influenza target, and the intersection target obtained is the predicted target of Yinqiao Ture granules against influenza. Cytoscape 3.8.0 software was used to construct a drug active ingredient-intersection target network model, and key active ingredients were selected. Use the STRING website to construct an intersection target protein interaction network (PPI) and select key target genes. Enriched analysis of GO and KEGG pathways using Metascape on intersection targets. Results: There are 136 active ingredients in Yinqiao Antipyretic Granules and 131 anti-influenza-related targets. Conclusion: The main components of Yinqiao Antipyretic Granules are quercetin, luteolin, naringenin, formononetin, IL-6, STAT3, MAPK14, CASP3 and other gene targets, to suppress inflammatory response, regulate immunity, reduce the symptoms of influenza, and thus play an anti-influenza therapeutic role.
    VL  - 4
    IS  - 4
    ER  - 

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Author Information
  • Department of Pharmacy, The First Affiliated Hospital of Jinan University, Guangzhou, China

  • Department of Pharmacy, The First Affiliated Hospital of Jinan University, Guangzhou, China

  • Department of Pharmacy, The First Affiliated Hospital of Jinan University, Guangzhou, China

  • Department of Pharmacy, The First Affiliated Hospital of Jinan University, Guangzhou, China

  • Department of Pharmacy, The First Affiliated Hospital of Jinan University, Guangzhou, China

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