Evidence is accumulating that suggests that cancer cell clusters are more likely to lead to metastatic lesions than are single cells. This mini-review explores this issue by examining evidence that indicates that cell clusters possess altered genes and metabolism that promote metastasis. When clusters are disaggregated, the resulting single cells often lose the altered properties characteristic of when they were in clusters. When cluster disrupting agents were injected into mice, metastasis was reduced. Cluster disaggregating agents are described and mechanisms of action of these compounds are explored. Using these agents to target cell clusters might offer a useful therapeutic approach in the treatment of cancer. Cell clusters are also involved in thrombocytosis and biofilm infectivity as well as cancer spread and cluster disrupting agents might be very useful in treating some human conditions in addition to cancer spread. Assays that examine the effectiveness of cluster disrupting agents are also described.
| Published in | American Journal of Applied Scientific Research (Volume 6, Issue 2) |
| DOI | 10.11648/j.ajasr.20200602.13 |
| Page(s) | 43-45 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2020. Published by Science Publishing Group |
Clustered Cancer Cells, Cancer Metastasis, Cluster Disrupting Agents
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APA Style
Steven Oppenheimer. (2020). Cell Clusters in Cancer Metastasis: A Mini Review. American Journal of Applied Scientific Research, 6(2), 43-45. https://doi.org/10.11648/j.ajasr.20200602.13
ACS Style
Steven Oppenheimer. Cell Clusters in Cancer Metastasis: A Mini Review. Am. J. Appl. Sci. Res. 2020, 6(2), 43-45. doi: 10.11648/j.ajasr.20200602.13
AMA Style
Steven Oppenheimer. Cell Clusters in Cancer Metastasis: A Mini Review. Am J Appl Sci Res. 2020;6(2):43-45. doi: 10.11648/j.ajasr.20200602.13
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Download@article{10.11648/j.ajasr.20200602.13,
author = {Steven Oppenheimer},
title = {Cell Clusters in Cancer Metastasis: A Mini Review},
journal = {American Journal of Applied Scientific Research},
volume = {6},
number = {2},
pages = {43-45},
doi = {10.11648/j.ajasr.20200602.13},
url = {https://doi.org/10.11648/j.ajasr.20200602.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajasr.20200602.13},
abstract = {Evidence is accumulating that suggests that cancer cell clusters are more likely to lead to metastatic lesions than are single cells. This mini-review explores this issue by examining evidence that indicates that cell clusters possess altered genes and metabolism that promote metastasis. When clusters are disaggregated, the resulting single cells often lose the altered properties characteristic of when they were in clusters. When cluster disrupting agents were injected into mice, metastasis was reduced. Cluster disaggregating agents are described and mechanisms of action of these compounds are explored. Using these agents to target cell clusters might offer a useful therapeutic approach in the treatment of cancer. Cell clusters are also involved in thrombocytosis and biofilm infectivity as well as cancer spread and cluster disrupting agents might be very useful in treating some human conditions in addition to cancer spread. Assays that examine the effectiveness of cluster disrupting agents are also described.},
year = {2020}
}
TY - JOUR T1 - Cell Clusters in Cancer Metastasis: A Mini Review AU - Steven Oppenheimer Y1 - 2020/05/19 PY - 2020 N1 - https://doi.org/10.11648/j.ajasr.20200602.13 DO - 10.11648/j.ajasr.20200602.13 T2 - American Journal of Applied Scientific Research JF - American Journal of Applied Scientific Research JO - American Journal of Applied Scientific Research SP - 43 EP - 45 PB - Science Publishing Group SN - 2471-9730 UR - https://doi.org/10.11648/j.ajasr.20200602.13 AB - Evidence is accumulating that suggests that cancer cell clusters are more likely to lead to metastatic lesions than are single cells. This mini-review explores this issue by examining evidence that indicates that cell clusters possess altered genes and metabolism that promote metastasis. When clusters are disaggregated, the resulting single cells often lose the altered properties characteristic of when they were in clusters. When cluster disrupting agents were injected into mice, metastasis was reduced. Cluster disaggregating agents are described and mechanisms of action of these compounds are explored. Using these agents to target cell clusters might offer a useful therapeutic approach in the treatment of cancer. Cell clusters are also involved in thrombocytosis and biofilm infectivity as well as cancer spread and cluster disrupting agents might be very useful in treating some human conditions in addition to cancer spread. Assays that examine the effectiveness of cluster disrupting agents are also described. VL - 6 IS - 2 ER -
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